1.

Verkhratsky Alexei Nestorovich

2.

(укр. та англ.)

3.

Посада, наукове звання/ступінь

Професор нейрофізіології, член Європейської Академії, голова секції фізіології та медицини Європейської Академії, головний редактор “Cell Calcium” (Elsevier; 2004 IF 5.2), доктор біологічних наук

Dr. Sc., PhD, MD

4.

Галузь досліджень (укр. та англ.)

Neurosciences; Physiology

5.

Перелік публікацій згідно з п.6 Засад Асоціації Засад Асоціації (1996-2006 рp.)

1. U. Lalo, Y. Pankratov, F. Kirchhoff, A. North & A. Verkhratsky (2006): NMDA receptors mediate neuron to glia signalling in mouse cortical astrocytes. Journal of Neuroscience, 26, 2673-83.
2. Y. Pankratov, U. Lalo, A. Verkhratsky & A. North (2006) Vesicular release of ATP at central synapses. Pflügers Archiv European Journal of Physiology, in press.
3. A. North & A. Verkhratsky (2006): Purinergic transmission in the central nervous system. Pflügers Archiv European Journal of Physiology, in press.
4. A. Verkhratsky (2006): Calcium ions and integration in neural circuits. Acta Physiologica, in press.
5. A. Verkhratsky & E. C. Toescu (2006): Neuronal-glial circuits as a substrate for CNS integration. Journal of Cellular and Molecular Medicine, in press.
6. D. Burdakov & A. Verkhratsky (2006): Biophysical re-equilibration of Ca²⁺ fluxes as a simple biologically plausible explanation for complex intracellular Ca²⁺ release patterns. FEBS Letters, v. 380, p. 463 - 468.
7. D. Burdakov, O. Gerasimenko & A. Verkhratsky (2005): Physiological changes in glucose differentially modulate the excitability of hypothalamic MCH and orexin neurons in situ. Journal of Neuroscience, v. 25, p. 2429 - 2433.
8. A. Verkhratsky (2005): Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiological Reviews, v. 85, p. 201 - 279.
9. O.H. Petersen, A Spät & A. Verkhratsky (2005): Introduction: reactive oxygen species in health and disease. Philosophical Transactions of the Royal Society: Biological Sciences, special issue, v. 360, p. 2197 - 2199.
10. D. Burdakov, S. Luckman & A. Verkhratsky (2005): Molecular physiology of glucose-sensing mechanisms in the CNS. Philosophical Transactions of the Royal Society: Biological Sciences, special issue, v. 360, p. 2227 - 2235.
11. O.H. Petersen, M. Michalak & A. Verkhratsky (2005): Calcium signalling: Past, present and future. Cell Calcium, v. 38, p.161 - 169.
12. D. Burdakov, O.H. Petersen & A. Verkhratsky (2005): Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium, v. 38, 303 - 310.
13. A. Verkhratsky (2005): Introduction to the Nervous System. In: Lecture notes on Human Physiology, Ed. by O. H. Petersen, Blackwells, in press
14. P. Pakhotin, A. J. Harmar, A. Verkhratsky & H.Piggins (2005): VIP receptors control excitability of suprachiasmatic nuclei neurones. Pflügers Archiv European Journal of Physiology, E-pub ahead of print.
15. T.-J. Huang, N. M. Sayers, A. Verkhratsky & P.Fernyhough (2005): Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats. Experimental Neurology, v. 194, p.279-283.
16. P. Pakhotin & A. Verkhratsky (2005): Electrical synapses between Bergmann glial cells and Purkinje neurones in rat cerebellar slices. Molecular & Cellular Neuroscience, v. 28, p. 79 - 84.
17. T.-Z. Huang, A. Verkhratsky & P. Fernyhough (2005): Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons. Molecular & Cellular Neuroscience, v. 28, p. 42 - 54.
18. S.A. Fedulova, A. Verkhratsky & N. Veselovsky (2004): Regulation of GABA release by depolarization-evoked Ca²⁺ transients at a single hippocampal terminal. Pflügers Archiv European Journal of Physiology, v. 448, p. 376 - 382.
19. N. Ismayilova, J. Brotchie, A. Verkhratsky & A. Crossman (2004): Effects of adenosine A1, dopamine D1 and metabotropic glutamate 5 receptors–modulating agents on locomotion of the reserpinised rats. European Journal of Pharmacology, v. 497, p. 187 - 195.
20. Xie Jiong, P.J. Camello, A. Verkhratsky & E. C. Toescu (2004): Mitochondrial polarisation status and [Ca²⁺]_i signalling in long-term cultures of rat cerebellar granule neurones. Neurobiology of Ageing, v. 25, p. 349 - 359.
21. A. Verkhratsky, M. Mattson & E.C. Toescu (2004): Aging in the mind. Trends in Neurosciences, v. 27, p.577 - 578.
22. E.C.Toescu, A. Verkhratsky & P. Landfield (2004): Calcium Regulation and Gene Expression in Normal Brain Aging. Trends in Neurosciences, v. 27, p. 614 - 620.
23. E.C. Toescu, A. Verkhratsky & M.P. Mattson (2004): Synaptic function and behavior during normal ageing. Ageing Research Reviews, v. 3, p. v.
24. A. Verkhratsky & S.A. Fedulova (2004): Calcium entry and intracellular calcium stores in regulation of neurotransmitter release. Fiziologichnyi Zhournal, 50, p. 142 – 149 (in Ukrainian).
25. S. Wray, U. Ravens, A. Verkhratsky & D. Eisner (2004): Two centuries of excitation-contraction coupling. Cell Calcium, v. 35, 485 - 489.
26. A. Verkhratsky (2004): Endoplasmic reticulum calcium signalling in nerve cells. Biological Research, v. 37, p. 693 - 699.
27. N. Solovyova & A. Verkhratsky (2004): Measurements of free Ca²⁺ concentration in the lumen of neuronal endoplasmic reticulum. In: Imaging Neuroscience, Ed. by R. Yuste & A. Konnerth, Cold Spring Harbor Laboratory Press.
28. E. C. Toescu & A. Verkhratsky (2004): Ca²⁺ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing. Journal of Cellular and Molecular Medicine, v. 8, p. 181 - 190.
29. D. Brough, R A. Le Feuvre, R. D. Wheeler, N. Solovyova, S. Hilfiker, N. J. Rothwell & A. Verkhratsky (2003): Ca²⁺ stores and Ca²⁺ entry differentially contribute to the release of IL-1b and IL-1a from murine macrophages. Journal of Immunology, v. 170, p. 3029-3036.
30. T.-J. Huang, S. Price, L. Chilton, N.A. Calcutt, D.R. Tomlinson, A. Verkhratsky & P. Fernyhough (2003): Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of Type I diabetic rats in the presence of sustained hyperglycemia. Diabetes, v. 52, p.2129-2136.
31. F. M. Ross, S. M. Allan, N. J. Rothwell & A. Verkhratsky (2003) A dual role for interleukin-1 in LTP in mouse hippocampal slices. Journal of Neuroimmunology, v.144. p. 61 - 67.
32. Yu. Pankratov, U. Lalo, O. Krishtal & A. Verkhratsky (2003): P2X receptor-mediated excitatory synaptic currents in somato-sensory cortex. Molecular & Cellular Neuroscience, v. 24, p. 842 - 849.
33. N. Solovyova & A. Verkhratsky (2003): Neuronal endoplasmic reticulum acts as a single functional Ca²⁺ store shared by ryanodine and inositol-1,4,5-trisphosphate receptors as revealed by intra-ER [Ca²⁺] recordings in single rat sensory neurones. Pflügers Archiv European Journal of Physiology, v. 446, p. 447 - 454.
34. E.C. Toescu & A. Verkhratsky (2003): Neuronal ageing from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria. Cell Calcium, v. 34, p. 311 - 323.
35. A. Verkhratsky & E. C. Toescu (2003): Endoplasmic reticulum Ca²⁺ homeostasis and neuronal death. Journal of Cellular and Molecular Medicine, v. 7, p. 351 - 361.
36. Fernyhough, P., Huang, T.Z. & A. Verkhratsky (2003): Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. Journal of the Peripheral Nervous System, v. 8, p. 227 - 235.
37. A. Verkhratsky (2003): Neurones and glia in cross-talk: Role of chemical and electrical synapses. In: 3rd FEPS Congress Proceedings, Ed. by P.Poujeol & O.H.Petersen, Monduzzi Editore, Bologna, p. 95 - 102.
38. N. Solovyova, N. Veselovsky, E.C. Toescu & A. Verkhratsky (2002): Ca²⁺ dynamics in the lumen of the endoplasmic reticulum in sensory neurones: direct visualisation of Ca²⁺-induced Ca²⁺ release triggered by physiological Ca²⁺ entry. EMBO J., v. 21, p. 622 - 630.
39. J. Xiong, A. Verkhratsky & E. C. Toescu (2002): Changes in mitochondrial status associated with altered Ca²⁺ homeostasis in aged cerebellar granule neurones in brain slices. Journal of Neuroscience, v. 22, p. 10761 - 10771.
40. T.-J. Huang, N. M. Sayers, P. Fernyhough & A. Verkhratsky (2002): Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3. Diabetologia, v. 45, p. 560 - 570.
41. N. Solovyova, P. Fernyhough, G. Glazner & A. Verkhratsky (2002): Xestospongin C empties the ER calcium store but does not inhibit InsP₃-induced Ca²⁺ release in cultured dorsal root ganglia neurones. Cell Calcium, v. 32, p. 49 - 52.
42. Yu. Pankratov, U. Lalo, O. Krishtal & A. Verkhratsky (2002): Ionotropic P_2X purinoreceptors mediate synaptic transmission in rat pyramidal neurons of layer II/III of somato-sensory cortex. Journal of Physiology (London), v. 542, p. 529 - 536.
43. D. V. Kiryushko, L. P. Savtchenko, A. Verkhratsky & S. M. Korogod (2002): Theoretical estimation of the capacity of intracellular calcium store in Bergmann glial cell. Pflügers Archiv European Journal of Physiology, v. 443, p. 643 - 651.
44. A. Verkhratsky (2002): The endoplasmic reticulum and neuronal calcium signalling. Cell Calcium, v. 32, 393 - 404.
45. M. D. Bootman, O. H.Petersen & A. Verkhratsky (2002): The endoplasmic reticulum is a focal point for co-ordination of cellular activity. Cell Calcium, v. 32, 231 - 234.
46. N. Solovyova, & A. Verkhratsky (2002): Monitoring of free calcium in the neuronal endoplasmic reticulum: An overview of modern approaches. Journal of Neuroscience Methods, v. 122, p. 1 - 12.
47. A. Verkhratsky, P.W. Landfield, P.W. & O. Thibault (2002): Calcium signaling and neuronal pathology. Preface. European Journal of Pharmacology, v. 447, 115-117.
48. A. Verkhratsky & O.H.Petersen (2002): The endoplasmic reticulum as an integrating signalling organelle: From neuronal signalling to neuronal death. European Journal of Pharmacology, v. 447, p. 141 - 154.
49. A. Verkhratsky, N. Solovyeva & E.C. Toescu (2002): Calcium excitability of glial cells. In: Glia in synaptic transmission, Ed. by A. Volterra, P. Haydon & P. Magistretti, OUP, p. 9 - 109.
50. A. Verkhratsky & O. Jones (2002): Astrocytic networks and brain injury. In: Immune and inflammatory responses in the nervous system, Ed. by N.Rothwell and S. Loddick, OUP p.24 - 35.
51. A. Verkhratsky & N. Solovyeva (2002): Alterations in the function of endoplasmic reticulum and neuronal signaling. Neurophysiology, v. 34, p. 131 - 136.
52. V. N. Dedov, S. Mandadi, P. J. Armati, & A. Verkhratsky (2001): The VR-1 vanilloid receptor sensitises mitochondria of dorsal root ganglia neurones to an uncoupling effect of capsaicin, mediated via inhibition of complex I of the respiratory chain. Neuroscience, v. 103, p. 219 - 226.
53. K.M. Schmidt-Ott, A.D. Xu, S. Tuschick, L. Liefeldt, W. Kresse, A. Verkhratsky, H. Kettenmann & M. Paul (2001): Hypoxia reverses dibutyryl-cAMP-induced stellation of cultured astrocytes via activation of the endothelin system. FASEB Journal, v. 15, p. 1227 – 1229.
54. A. Verkhratsky (2001): Glial calcium signalling and neuronal-glial interactions. In Calcium Signalling, Ed. By M. Morad & P. Kostyuk, p. 137 - 144.
55. E.C.Toescu & A.Verkhratsky (2001): Principles of Fluorescence Measurements - Dyes and Hardware Required. In: Measuring Calcium and Calmodulin Inside and Outside Cells, Ed. by O.H.Petersen, Springer-Verlag p. 3 - 45.
56. E C. Toescu, A. Verkhratsky (2000): Neuronal ageing in long-term cultures: Alterations of Ca²⁺ homeostasis. NeuroReport, v. 11, p. 3725-3730
57. E.C.Toescu & A. Verkhratsky (2000): Assessment of mitochondrial polarisation status in living cells based on analysis of spatial heterogeneity of Rhodamine 123 fluorescence staining. Pflügers Archiv European Journal of Physiology, v. 440, p. :941 - 947.
58. T. Möller, O. Kann, A. Verkhratsky & H. Kettenmann (2000): Activation of mouse microglial cells affects P₂ receptor signalling. Brain Research, v. 853, p. 49 - 59.
59. A. Minelli, S. Lyons, C. Nolte, A. Verkhratsky & H. Kettenmann (2000): Ammonium triggers calcium elevation in cultured microglial cells by initiating Ca²⁺ release from thapsigargin-sensitive intracellular stores. Pflügers Archiv European Journal of Physiology v. 439, p. 370 - 377.
60. E. Toescu & A. Verkhratsky (2000): Parameters of calcium homeostasis in normal neuronal ageing. Journal of Anatomy, v. 197, p. 563 - 569.
61. E.C. Toescu, N. Myronova & A. Verkhratsky (2000): Age-related structural and functional changes of brain mitochondria. Cell Calcium, 28, 329 - 338.
62. A. Verkhratsky & C. Steinhäuser (2000): Ion channels in glial cells. Brain Research Reviews, v.32, p. 380 - 412.
63. A. Verkhratsky & E.C.Toescu (2000): Calcium and cellular ageing. In: Calcium and Cellular Function, Ed. By R. Pochet, Kluwer, p. 277 - 286.
64. E.C. Toescu & A. Verkhratsky (2000): Calcium and Neuronal Ageing. Differences between normal ageing and neurodegeneration. In: Alzheimer European Yearbook, p. 271 - 276.
65. S. Kirischuk, F. Kirchhoff, V. Matyash, H. Kettenmann & A. Verkhratsky (1999): Glutamate-triggered Ca²⁺ signalling in mouse Bergmann glial cells in situ: role of InsP3-mediated intracellular Ca²⁺ release. Neuroscience, v.92, p.1051 - 1059.
66. J. Grosche, V. Matyash, T. Möller, A. Verkhratsky, A. Reichenbach & H. Kettenmann (1999): Microdomains for neurone-glia interaction: Parallel fiber stimulation signals to substructures of Bergmann glial cells. Nature Neuroscience, v. 2, p. 139 - 143.
67. D.F.Condorelli, F.Conti, V.Gallo, F.Kirchhoff, G.Seifert, C.Steinhäuser, A.Verkhratsky & X. Yuan (1999): Expression and functional analysis of glutamate receptors in glial cells. Advances in Experimental Medical Biology, v. 468, p. 49 - 67.
68. J. Hartmann & A.Verkhratsky (1998): Relations between intracellular Ca²⁺ stores and store-operated Ca²⁺ entry in primary cultured human glioblastoma cells. Journal of Physiology, London, v.513, p. 411 - 424.
69. E. C. Toescu, T. Möller, H. Kettenmann & A.Verkhratsky (1998): Long-term activation of capacitative Ca²⁺ entry in mouse microglial cells. Neuroscience, v. 86, p. 925 - 935.
70. K.M.Schmidt-Ott, S.Tuschick, F.Kirchoff, A.Verkhratsky, L.Liefeldt, H.Kettenmann & M.Paul (1998): Single-cell characterization of endothelin system gene expression in the cerebellum in situ. Journal of Cardiovascular Pharmacology, v. 31, Suppl. 1, p. S364 - S366.
71. A. Verkhratsky & O.H. Petersen (1998): Neuronal calcium stores. Cell Calcium, v. 24, p. 333 - 343.
72. J.W.Deitmer, A.Verkhratsky & C. Lohr (1998): Calcium signalling in glial cells. Cell Calcium, v. 24, p. 405 - 416.
73. E.C.Toescu & A.Verkhratsky (1998): Principles of calcium signalling. In: Integrative Aspects of Calcium Signalling, Plenum Press, p. 2 - 22.
74. A. Verkhratsky & E.C.Toescu (1998): On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology. Trends in Neurosciences, v. 21, p. 286 - 287.
75. A. Verkhratsky & E.C.Toescu (1998): Calcium and neuronal ageing. Trends in Neurosciences, v. 21, p. 2 - 6.
76. A. Verkhratsky, R.Orkand & H.Kettenmann (1998): Glial calcium: homeostasis and signalling function. Physiological Reviews, v. 78, 99 - 141.
77. P. Kostyuk & A. Verkhratsky (1998): Basic properties of calcium release channels in neural cells. In: Pharmacology of Ion Channels, Ed. by B. Soria, Oxford University Press, Oxford et al. p. 299 - 320.
78. T. Möller, C. Nolte, R. Burger, A. Verkhratsky & H. Kettenmann (1997): Mechanisms of C5a and C3a complement-fragments induced [Ca²⁺]_i signalling in mouse microglia. Journal of Neuroscience, v.17, 615 - 624.
79. S. Kirischuk, H.Kettenmann & A.Verkhratsky (1997): Na⁺/Ca²⁺ exchanger modulates kainate-triggered Ca²⁺ signalling in Bergmann glial cells in situ. FASEB Journal, v. 11, p. 566 - 572.
80. N. Svichar, P. Kostyuk & A. Verkhratsky (1997): Mitochondria buffer Ca²⁺ entry but not intracellular Ca²⁺ release in mouse DRG neurones. NeuroReport, v. 8, p. 3929-3932.
81. S. Tuschick, S. Kirischuk, F. Kirchhoff, L. Liefeldt, M. Paul, A. Verkhratsky & H. Kettenmann (1997): Bergmann glial cells in situ express endothelin_B receptors linked to cytoplasmic calcium signals. Cell Calcium, v. 21, p.408 - 419
82. N. Svichar, A. Shmigol, A. Verkhratsky & P. Kostyuk (1997): ATP induces Ca²⁺ release from InsP₃-sensitive Ca²⁺ stores exclusively in large DRG neurones. NeuroReport, v. 8, p. 1555-1559.
83. T. Möller, O. Kann, M. Prinz, F. Kirchhoff, A. Verkhratsky & H. Kettenmann (1997): Endothelin induced calcium signaling in cultured mouse microglial cells is mediated through ET_B receptors. NeuroReport, v. 8, p. 2127-2131.
84. N. Svichar, A. Shmigol, A. Verkhratsky & P. Kostyuk (1997): InsP₃-induced Ca²⁺ release in dorsal root ganglion neurones. Neuroscience Letters, v. 227, p. 107-110.
85. V.Matyash & A.Verkhratsky (1997): Expression of type I metabotropic glutamate receptors in Purkinje neurones of mice. Neurophysiology (Kiev), v.29, p. 1- 4.
86. V. Matyash, S. Kirischuk & A.Verkhratsky (1997): Expression and functional properties of glutamate receptors in Bergmann glial cells in situ. Journal of Academy of Medical Sciences of the Ukraine, v. 3, p. 100 - 111 (in Ukrainian).
87. A. Verkhratsky (1997): Calcium signalling in glial cells. In: Proceedings of the IUPS workshop on Intracellular signalling, Neurophysiology (Kiev), v. 29, p. 263 - 272.
88. S. Kirischuk & A. Verkhratsky (1996): Calcium homeostasis in aged neurones. Life Sciences, v. 59, p. 451 - 459.
89. S. Kirischuk, V. Matiash, A. Kulik, N. Voitenko, P. Kostyuk & A. Verkhratsky (1996): Activation of P₂-purino-, a₁-adreno- and H₁-histamine receptors triggers cytoplasmic calcium signalling in cerebellar Purkinje neurones. Neuroscience, v.73, p. 643 - 647.
90. S. Haas, J. Brockhaus, A. Verkhratsky & H. Kettenmann (1996): ATP-induced membrane currents in ameboid microglia acutely isolated from mouse brain slices. Neuroscience, v.75, p. 257 - 261.
91. S. Kirischuk, S. Tuchek, A. Verkhratsky & H. Kettenmann (1996) Calcium signalling in mouse Bergmann glial cells mediated by a₁-adrenoreceptors and H₁ histamine receptors European Journal of Neurosciences, v.8, p. 1198-1208.
92. S. Kirischuk & A. Verkhratsky (1996): [Ca²⁺]_i recordings from neural cells in acutely isolated cerebellar slices employing differential loading of membrane permeant form of calcium indicator fura-2. Pflügers Archiv European Journal of Physiology, v.431, p. 977 - 983.
93. S. Kirischuk, N. Voitenko, P. Kostyuk & A. Verkhratsky (1996): Calcium signalling in granule neurones studied in cerebellar slices. Cell Calcium, v.19, p. 59-71.
94. A. Shmigol, N. Svichar, P. Kostyuk & A. Verkhratsky (1996): Gradual caffeine-induced Ca²⁺ release in mouse dorsal root ganglion neurons is controlled by cytoplasmic and luminal Ca²⁺. Neuroscience, v.73, p. 1061 - 1067.
95. S. Kirischuk, N. Voitenko, P. Kostyuk & A. Verkhratsky (1996): Age-associated changes of cytoplasmic calcium homeostasis in cerebellar granule neurons in situ: investigation on thin cerebellar slices. Experimental Gerontology, v.31, p. 475 - 487.
96. A. Verkhratsky & H. Kettenmann (1996): Calcium signalling in glial cells. Trends in Neurosciences, v.19, p. 346 - 352.
97. A. Verkhratsky & A. Shmigol (1996): Calcium-induced calcium release in nerve cells. Cell Calcium, v. 19, p. 1-14.

6.

Контакт (на власний розсуд: телефон/email/homepage/

поштова адреса)

alex.verkhratsky@manchester.ac.uk